Simulation of conformational preconditioning strategies for electrophoretic stretching of DNA in a microcontraction     

Hsieh CC  Lin TH 《Biomicrofluidics》2011,5(4):44106-4410617

We have used Brownian dynamics-finite element method to examine two conformational preconditioning approaches for improving DNA stretching in a microcontraction for the purpose of direct gene analysis. The newly proposed "pre-stretching" strategy is found to significantly improve the degree of DNA extension at the exit of the contraction. On the other hand, applying an oscillating extensional field to DNA yields no preconditioning effect. Detailed analysis of the evolution of DNA extension and conformation reveals that the success of our "pre-stretching" strategy relies on the "non-local" effect that cannot be predicted using simple kinematics analysis. In other words, accurate prediction can only be obtained using detailed simulations. Comparing to the existing preconditioning strategies, our "pre-stretching" method is easy to implement while still providing a very good performance. We hope that the insight gained from this study can be useful for future design of biomicrofluidic devices for DNA manipulation.  相似文献   

Student factors related to learning in biomechanics     

Hsieh C  Knudson D 《Sports biomechanics / International Society of Biomechanics in Sports》2008,7(3):398-402

The aim of this study was to identify the student behaviours and characteristics that are related to learning biomechanical concepts. The Biomechanics Concept Inventory (BCI) was given to 53 kinesiology majors before and after an introductory biomechanics class together with a survey of student behaviours to determine factors that assisted in learning. Analysis of scores from 49 students showed significant (P < 0.001) improvement following instruction. Variables that significantly (P < 0.05) and uniquely correlated with improvement were grade point average (r = 0.46) and student interest in biomechanics (r = 0.41). Thirty-one percent of the variance in learning could be accounted for by these two variables, with no distinctive associations with student behaviours like course reading, hours studying, and credits earned in maths and physics. However, grade point average was significantly correlated with several student behaviour variables. Consequently, student learning of biomechanical concepts is likely a complex phenomenon with individual learning related to variables that interact with student interest and overall academic ability.  相似文献   

International programs of the National Library of Medicine     

R K Hsieh 《Bulletin of the Medical Library Association》1988,76(1):54-57

The National Library of Medicine (NLM) has a broad mission in biomedical information service. There are three major reasons for NLM, as a national institution, having an international program: first, the global nature of disease; second, the international scope of medical literature; and third, the universal goal of better communication. This paper reviews NLM's programs in relation to international medical information exchange: International MEDLARS Centers, collaboration with WHO and PAHO, NLM Special Foreign Currency Program, and development of the NLM collection.  相似文献   

The impact of knowledge stickiness on knowledge transfer implementation,internalization, and satisfaction for multinational corporations     

Chia-Ying Li  Chang-Tseh Hsieh 《International Journal of Information Management》2009

Improving the effectiveness of knowledge transfer from a parent firm to its subsidiary is one of the most critical issues confronting management at multinational companies (MNC). Since knowledge tends to be sticky and difficult to transfer, the success of knowledge transfer is contingent not only upon various kinds of contextual variables, but also upon the process of knowledge transfer implementation and internalization. Previous studies did not consider the process of implementation and internalization variables, and failed to provide a more comprehensive research framework for MNC knowledge transfer. This study attempts to assess the impact of knowledge stickiness on knowledge transfer implementation and internalization, as well as the performance of headquarter–subsidiary knowledge transfer. Results of this study suggest that an increase in knowledge stickiness may have a positive and significant influence on knowledge implementation, internalization, and knowledge transfer satisfaction. However, increases in knowledge stickiness beyond a certain point can also deter the success of transferring knowledge. Results also suggest a significant relationship between knowledge transfer implementation and internalization, innovation and satisfaction, and between knowledge innovation and knowledge transfer satisfaction.  相似文献   

Exploring students’ conceptions of science learning via drawing: a cross-sectional analysis     

Wen-Min Hsieh 《International Journal of Science Education》2013,35(3):274-298

ABSTRACT

This cross-sectional study explored students’ conceptions of science learning via drawing analysis. A total of 906 Taiwanese students in 4th, 6th, 8th, 10th, and 12th grade were asked to use drawing to illustrate how they conceptualise science learning. Students’ drawings were analysed using a coding checklist to determine the presence or absence of specified attributes. Data analysis showed that the majority of students pictured science learning as school-based, involving certain types of experiment or teacher lecturing. In addition, notable cross-sectional differences were found in the ‘Activity’ and ‘Emotions and attitudes’ categories in students’ drawings. Three major findings were made: (1) lower grade level students conceptualised science learning with a didactic approach, while higher graders might possess a quantitative view of science learning (i.e. how much is learned, not how well it is learned), (2) students’ positive and negative emotions and attitudes toward science learning reversed around middle school, and (3) female students expressed significantly more positive emotions and attitudes than their male counterparts. In conclusion, higher graders’ unfruitful conceptions of science learning warrant educators’ attention. Moreover, further investigation of girls’ more positive emotions and attitudes found in this study is needed.  相似文献   

Learning illustrated: An exploratory cross-sectional drawing analysis of students' conceptions of learning     

Wen-Min Hsieh 《The Journal of educational research》2018,111(2):139-150

Using the draw-a-picture technique, the authors explored the learning conceptions held by students across grade levels. A total of 1,067 Taiwanese students in Grades 2, 4, 6, 8, 10, and 12 participated in this study. Participants were asked to use drawing to illustrate how they conceptualize learning. A coding checklist was developed to analyze the features in the students' drawings. Consistent with previous study, the majority of the students' drawings portrayed learning happening in a traditional classroom that is teacher centered, with students depicted as passive listeners. Additionally, three main findings were obtained: (a) younger students held episodic images of learning as opposed to more mature students, (b) the human agents involved in learning shifted from others to self, and (c) negative emotions and attitudes reached a plateau in Grades 6, 8, and 10. The results of the study suggested possible cognitive and emotional developmental trends that warrant further investigation.  相似文献   

An investigation of knowledge‐building activities in an online community of practice at Subaru of America     

Susan M. Land  Darryl C. Draper  Ziyan Ma  Hsiu‐Wei Hsieh  Brian K. Smith  Robert Jordan 《Performance Improvement Quarterly》2009,22(3):23-36

Current approaches to workplace learning emphasize designing communities of practice that are intended to support both formal and informal knowledge acquisition. This article presents the design and research of a knowledge‐based community of practice for Subaru, based on principles outlined by Scardamalia (2002) and Zhang, Scardamalia, Lamon, Messina, and Reeve (2007). The purpose of this study was to investigate the extent to which participants' interactions in the online community showed evidence of individual and collective knowledge building. We found evidence of knowledge building within online discussions in these areas: interactions around improvement of ideas, connection to workplace knowledge and practices, and building on or adopting the ideas of others. We also found significant gains in scores on an assessment of workplace customer service after participation in the online community of practice.  相似文献   

Does student learning style affect performance on different formats of biomechanics examinations?     

Hsieh C  Mache M  Knudson D 《Sports biomechanics / International Society of Biomechanics in Sports》2012,11(1):108-119

Students' learning style preferences have been widely adapted into teaching and learning environments. The purpose of this study was to investigate the relationship between self-reported and assessed learning style preferences (visual, auditory, reading/writing, kinesthetic: VARK) on performance in different types of multiple-choice examinations (T1: text only format and T2: visual format) given in an introductory biomechanics class. Students who enrolled in three biomechanics classes at a state university were recruited to participate in the study. Ninety students (47 males and 43 females) completed a learning style survey and two types of examinations. Results showed that approximately half of the students were assessed and self-reported as kinesthetic for their preferred learning style. There was no significant difference in test performance between students who preferred visual and reading/writing learning styles (self-reported and assessed). These students demonstrated similar learning and comprehension of biomechanical concepts regardless of whether the test material was presented in their preferred sensory mode or not. Interestingly, female students' perceptions of their learning style preference may have a positive effect on the test results when the test is presented in their preferred format.  相似文献   

Developing Design through a Creative Problem‐Solving Process: A Group Community Art Project          下载免费PDF全文

Chia‐Ying Hsieh 《The International Journal of Art & Design Education》2018,37(3):541-553

For the past few years, creativity has gradually become an important element in the national cultivation of talent in Taiwan. Although traditionally art education is closely linked with creativity, the academic research on general art education is very insufficient. Therefore, the goal of this research is to investigate how creativity could be cultivated in curriculum planning for general art education at technology universities as well as what students’ learning process was when they participated in a course's creative activity. The research applied the theory and steps of creative problem‐solving (CPS) on a general art course to design a group practical activity combining with the local community. This involved converting the steps of creative problem‐solving into different stages of group design activities with the goal of constructing a design process equivalent to the process of problem‐solving. The main research results revealed that students could experience the problem‐solving process through group design activities and develop their divergent and convergent thinking at the same time. Moreover, the cooperative learning model is the most appropriate teaching strategy for students from non‐art‐related departments when cultivating their creativity.  相似文献   

Important learning factors in high- and low-achieving students in undergraduate biomechanics     

ChengTu Hsieh  Duane Knudson 《Sports biomechanics / International Society of Biomechanics in Sports》2018,17(3):361-370

The purpose of the present study was to document crucial factors associated with students’ learning of biomechanical concepts, particularly between high- and-low achieving students. Students (N = 113) from three introductory biomechanics classes at two public universities volunteered for the study. Two measures of students’ learning were obtained, final course grade and improvement on the Biomechanics Concept Inventory version 3 administered before and after the course. Participants also completed a 15-item questionnaire documenting student learning characteristics, effort, and confidence. Partial correlations controlling for all other variables in the study, confirmed previous studies that students’ grade point average (p < 0.01), interest in biomechanics, (p < 0.05), and physics credits passed (p < 0.05) are factors uniquely associated with learning biomechanics concepts. Students’ confidence when encountering difficult biomechanics concepts was also significantly (p < 0.05) associated with final grade. There were significant differences between top 15% and bottom 15% achievers on these variables (p < 0.05), as well as on readings completed, work to pay for college per week, and learning epistemology. Consequently, instructors should consider strategies to promote students’ interest in biomechanics and confidence in solving relevant professional problems in order to improve learning for both low- and high-ability students.  相似文献